Introduction to Bioinformatics for Medical Research
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Introduction to Bioinformatics for Medical Research
Introduction to Bioinformatics for Medical Research
This note introduces a wide range of bioinformatics tools and
concepts for application in medical research. This note is data-centric and
focuses on practical use but introduces a few basic theoretical issues too.
Topics covered includes: Introduction to Data Formats, Genomic Sequence
Alignment, Protein Sequence Alignment, Advanced BLAST , Motifs and Motif
Finding, Motif Databases and Gene Finding, Multiple Alignment and Phylogeny,
Protein Secondary Structure, Protein Tertiary (3D) Structure, Microarrays and
Expression Data,The Human Genome Project, Probe Design and Gene Networks,
Genetic Mapping.
This note
covers the following topics: what is bioinformatics, Path to the bioinformatics, Scope of computational biology, The Central Dogma of
Molecular Biology, Genomics, Proteomics, Killer application, Cells, Signaling
Pathways Control gene activity, DNA the code of life and genetic information
chromosomes.
This page covers the
following topics related to Bioinformatics : Text Mining Gene Selection to
Understand Pathological Phenotype Using Biological Big Data, Single-Cell RNA
Sequencing Procedures and Data Analysis, Computational Methods for Detecting
Large-Scale Structural Rearrangements in Chromosomes, Machine Learning
Approaches for Biomarker Discovery Using Gene Expression Data, Bayesian
Inference of Gene Expression, Comprehensive Evaluation of Error-Correction
Methodologies for Genome Sequencing Data, Plant Transcriptome Assembly: Review
and Benchmarking,WeMine Aligned Pattern Clustering System for Biosequence
Pattern Analysis, Rational Design of Profile Hidden Markov Models for Viral
Classification and Discovery, Pattern Discovery and Disentanglement for Aligned
Pattern Cluster Analysis and Protein Binding Complexes Detection.
This note covers the
following topics: Molecular Biology, Molecular Biology Information - DNA,
Protein Sequence, Macromolecular Structure and Protein Structure Details, Gene
Expression Datasets, New Paradigm for Scientific Computing, General Types of
Informatics in Bioinformatics, Genome Sequence, Protein Sequence, Major
Application: Designing Drugs, Finding Homologues, Genome Characterization.
This book covers
the following topics: Machine Learning in Bioinformatics, Theoretical
Background of Machine Learning, Support Vector Machines, Error Minimization and
Model Selection, Neural Networks, Bayes Techniques, Feature Selection, Hidden
Markov Models.