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Excerpt
Broadly speaking, the cause or the etiologic agent responsible for producing atherosclerosis remains unknown. The most widely accepted theory is “Response-to-Injury,” but the initiating injurious agent has yet to be identified. Until the injurious agent is identified, we must treat the symptoms and manifestations produced by the injurious agent rather than the agent itself...a poor bargain for the clinician.
This book attempts to show the nature and characteristics of the injurious agent through study of the gross and microscopic changes taking place in the coronary arteries of patients with and without clinical coronary disease. The specific injurious agent(s) may be unknown, but we can characterize the agent(s) to gain a deeper understanding of the processes involved.
Contents
- Preface
- Acknowledgements
- Introduction
- Chapter 1. The Beginnings. A Multicentric Disease
- Chapter 2. The Smooth Muscle Cell. The Pivot in Atherosclerosis
- Chapter 3. Inflammation. A Sign of Active Disease
- Chapter 4. Atheromas Are Caseous Abscesses
- Chapter 5. Calcification: A Physiologic Defense
- Aging and Vascular Calcification
- Calcification and Luminal Stenosis
- Luminal Stenosis without Calcification
- Calcification Is Similar to Bone Formation
- Matrix Vesicles
- Osteoid
- Osteoid and Atherosclerotic Calcification
- Normal Bone and Cartilage
- Evolutionary Purpose
- Reversibility of Coronary Calcification
- Sequence of Events
- In Review
- Chapter 6. Adventitia – The Ultimate Defense
- Chapter 7. Surface Erosions
- Chapter 8. Blind Pockets and False Channels
- Chapter 9. Thrombosis and the Injurious Agent
- Chapter 10. Chronic Ulcerated Plaques
- Chapter 11. What Is the Injurious Agent?
- Chapter 12. The Toxic Atheroma
- Chapter 13. Plaque Toxins and Clinical Coronary Syndromes
- The Pathogenesis of Angina Pectoris Pain
- Variant (Prinzmetals) Angina (VA)
- Sudden Cardiac Death (SCD)
- Unstable Angina (UA) and Non S-T Segment Elevation Myocardial Infarction (NSTEMI)
- S-T Elevation Myocardial Infarction (STEMI)
- Thrombosis versus Plaque Toxins
- Myocardial Rupture and Thrombolytic Drugs
- Stunned Myocardium
- Silent Ischemia (SI)
- Oral IIB/IIIA Inhibitors
- Aspirin (ASA), UPs, and Plaque Toxins
- Conclusions
- Future Directions
- The Injection Technique
- References
- Abbreviations
Medical knowledge is constantly changing. As new information becomes available, changes in treatment, procedures, equipment and the use of drugs become necessary. The author and the publishers have, as far as it is possible, taken care to ensure that the information given in this text is accurate and up-to-date. However, readers are strongly advised to confirm that the information, especially with regard to drug usage, complies with the latest legislation and standards of practice.
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