This note covers the
following topics: Structural Biology and Amino acids, History of Macromolecular Crystallography, Amino acid Chirality,
Non-covalent interactions and Ramachandran Map, Secondary structures;
Introduction to Protein , Alpha-domain proteins I: Coiled coils and four-helix
bundle, ROP protein design, Alpha-domain proteins II: Large alpha-helical domain
and globin fold, Alpha or Beta-domain proteins, Beta-domain proteins.
This book combines a
general overview of diffraction methods with a step-by-step description of the
process of a single-crystal X-ray structure determination experiment, from
chemical synthesis or expression to phasing and refinement, analysis and quality
control . Topics covered includes: Major techniques in structural biology, X-ray
fiber diffraction, Electron diffraction, Electron microscopy, Neutron
diffraction, Nuclear magnetic resonance spectroscopy, Single crystal X-ray
crystallography.