Antivirals Virology
The contents 
of this lecture presentation include : Vaccines can prevent viral disease, Why 
are there so few antiviral drugs?, Antiviral history, Blind screening, Antiviral 
discovery today, The path of drug discovery, Mechanism-based screens, Cell-based 
screen, Antiviral screening, High throughput screening, Dangers of drug 
resistance, Mechanisms of drug resistance, Acyclovir mechanism of action, 
Improving acyclovir, Acyclovir-resistant HSV, Symmetrel, Influenza virus NA 
inhibitors, WIN compounds, Inhibitors of picornavirus uncoating, New HCV drugs, 
HCV new drug pipeline, Azido-deoxythymidine, AZT, Non-nucleoside RT inhibitors, 
IN inhibitors, Maraviroc: CCR5 inhibitor, Combination therapy, Mathematics of 
drug resistance, ART saves lives, Pre-exposure prophylaxis.
Author(s): Prof. Vincent Racaniello, Columbia University
 61 Pages
61 Pages