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This note covers the following topics: Structure of DNA, Base-pair Interactions and DNA Melting, Mechanics and Statistical Mechanics of DNA, Electrostatics of DNA and DNA -DNA Interactions, DNA Collapse and DNA Mesophases, DNA Organization in Chromatin and Viruses.
Author(s): Rudi Podgornik
320Pages
This introductory note on biophysics introduces the principles of electrical excitability of cell membranes, which form the basis of all information processing in the nervous system. Topics covered includes: neurons and the brain, Electrical properties of cells, Hodgkin-Huxley model of action potentials, Synapses and Perceptrons.
Author(s): Bert Kappen
97Pages
The topics that will be presented this note include an introduction to the elementary structure of DNA, proteins, membranes, and cells, and the physical principles that govern the resulting structures.
Author(s): Prof. Brigita Urbanc
NAPages
The topics that will be presented in this course note include an introduction to the elementary structure of DNA, proteins, membranes, and cells, and the physical principles that govern the resulting structures. Here, the physical quantities such as temperature, energy, enthalpy, entropy, and free energy will be employed to understand why a biological system chooses particular state at conditions under study.
Author(s): Brigita Urbanc
NAPages
This note covers the following topics: Minimal Biosystems, Optimal BioSystems, DNA: Genotyping and Biome sequencing, RNA: Quantitation concepts and Clustering by gene or condition and other regulon data sources, Protein: 3D structural genomics, homology, catalytic and regulatory dynamics, function and drug design, Mass spectrometry, post-synthetic modifications, quantitation of proteins, metabolites and interactions.
Author(s): George Church
NAPages
This note covers the following topics: Michaelis-Menten kinetics, equilibrium binding, Lambda phage, multistability, synthetic genetic switches, stability analysis, introduction to E.coli chemotaxis, Fine-tuned versus Robust chemotaxis models, wrapping up chemotaxis, genetic oscillators, stochastic chemical kinetics, cell systems biology-'the importance of diffusion and gradients for cellular regulation', Quorum sensing, Drosophila development.
Author(s): Prof. Alexander van Oudenaarden
NAPages
This course provides a survey of problems at the interface of statistical physics and modern biology. Topics covered includes: bioinformatic methods for extracting information content of DNA, gene finding, sequence comparison, and phylogenetic trees, physical interactions responsible for structure of biopolymers, DNA double helix, secondary structure of RNA, and elements of protein folding, considerations of force, motion, and packaging, protein motors and membranes.
Author(s): Prof. Mehran Kardar and Prof. Leonid Mirny
NAPages
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