This PDF covers the following
topics related to Mass Spectrometry : Introduction to Mass Spectrometry, Peptide
De Novo Sequencing, Combinatorics of Weighted Strings, Database Searching and
Comparing Mass Spectra, Significance: p-values and E-values, Significance:
Decoy Databases and False Discovery Rates, Isotope Distributions and Isotope
Patterns, Decomposing Isotope Patterns, Fragmentation trees, Searching
metabolite structure databases, Glycan De Novo Sequencing, Priors and Machine
Learning, The missing chapters, Mathematics and computer science, Conclusion.
This PDF covers the following
topics related to Mass Spectrometry : Introduction to Mass Spectrometry, Peptide
De Novo Sequencing, Combinatorics of Weighted Strings, Database Searching and
Comparing Mass Spectra, Significance: p-values and E-values, Significance:
Decoy Databases and False Discovery Rates, Isotope Distributions and Isotope
Patterns, Decomposing Isotope Patterns, Fragmentation trees, Searching
metabolite structure databases, Glycan De Novo Sequencing, Priors and Machine
Learning, The missing chapters, Mathematics and computer science, Conclusion.
The
major focus of the note is understanding mass spectra, so the majority of the
problem sets will involve interpretation of mass spectra of unknowns. Topics
covered includes: Interpretation of Electron Impact, Ion sources, Mass
Analyzers, MS/MS and fragmentation methods, Mass Spectrometry in the Real World,
Protein complexes and ydrogen and Deuterium Exchange, Imaging Mass Spectrometry,
2D FTICR mass spectrometry.
This book serves multiple groups of
audiences; professional, graduate students and general
readers interested in the use of modern mass spectrometry in solving critical
questions of chemical and biological sciences. The areas covered include the
analysis of drugs, metabolites, carbohydrates and protein post-translational
modifications.
Author(s): Ana Varela Coelho
and Catarina de Matos Ferraz Franco
This note covers
the following topics: Sample Introduction, Ionization Techniques, Electron
Ionization, Chemical Ionization, Mass Analyzers, Detectors, Vacuum System, Data
System, Interpretation.
This course note
will develop Mass Spectrometry as an analytical tool in chemistry and
biochemistry, at an advanced level. Topics covered includes ionization, mass
analyzers, ion dissociation, ion mobility, qualitative and quantitative analysis
with various applications.