In mass spectrometry, one generates ions from a
sample to be analyzed. These ions are then separated and quantitatively
detected. The units covered in this notes are as follows : Introduction, Charge
Location and Fragmentation, Ion Separation, Ionization and Desorption,
Biomolecules, Literature, Sources.
Author(s): Peter
M. van Galen and Martin C. Feiters, Department of Organic Chemistry, Molecular
Chemistry Cluster, Institute for Molecules and Materials, Faculty of Science,
Radboud University, Nijmegen
This book serves as an introduction to
tandem mass spectrometry (MS/MS) and its role in molecular characterization in
chemical and biological research areas. It is tailored to professionals and
students alike and assesses the application of MS/MS in studying complex
molecules such as drugs, metabolites, carbohydrates, and proteins. The authors
explain how tandem mass spectrometry can provide detailed structural information
and insights into post-translational modifications. This resource is ideal for
those looking to understand the powerful applications of MS/MS in molecular
biology and chemistry, with emphasis on its versatility in biological and
pharmaceutical sciences.
Author(s): Ana Varela Coelho
and Catarina de Matos Ferraz Franco
This note gives
a fairly accessible introduction to the principles and applications of mass
spectrometry. It starts by outlining important topics, such as sample
introduction, ionization techniques (electron and chemical ionization), and mass
analyzers. It then discusses the different types of detectors and the vacuum
systems required for successful analysis. It offers a tutorial overview of how
mass spectrometry can be applied to the analysis of complex chemical systems,
including an introduction to data systems and interpretation techniques. This
note is perfect for newcomers in the analytical chemistry arena seeking to get a
good grasp of the basics of mass spectrometry.