major focus of the note is understanding mass spectra, so the majority of the
problem sets will involve interpretation of mass spectra of unknowns. Topics
covered includes: Interpretation of Electron Impact, Ion sources, Mass
Analyzers, MS/MS and fragmentation methods, Mass Spectrometry in the Real World,
Protein complexes and ydrogen and Deuterium Exchange, Imaging Mass Spectrometry,
2D FTICR mass spectrometry.
This PDF covers the following
topics related to Mass Spectrometry : Introduction to Mass Spectrometry, Peptide
De Novo Sequencing, Combinatorics of Weighted Strings, Database Searching and
Comparing Mass Spectra, Significance: p-values and E-values, Significance:
Decoy Databases and False Discovery Rates, Isotope Distributions and Isotope
Patterns, Decomposing Isotope Patterns, Fragmentation trees, Searching
metabolite structure databases, Glycan De Novo Sequencing, Priors and Machine
Learning, The missing chapters, Mathematics and computer science, Conclusion.
This guide introduces young children to mass
spectrometry and give them the opportunity to experience a modern research
laboratory. The modules in this note are highly adaptable and can be applied to
young children from the age of 6 years to 14 years.
This course note
will develop Mass Spectrometry as an analytical tool in chemistry and
biochemistry, at an advanced level. Topics covered includes ionization, mass
analyzers, ion dissociation, ion mobility, qualitative and quantitative analysis
with various applications.