Prof.
Peter B. O'Connor's note on mass spectrometry. It deals with the interpretation
of mass spectra; it would be particularly useful for any persons undertaking the
analysis of unknown samples. It starts by dealing with a range of techniques,
among them being electron impact ionization, MS/MS fragmentation, and ion
sources. In addition, the note goes into practical implementations of mass
spectrometry in real-world applications such as protein complex analysis,
hydrogen and deuterium exchange, and imaging mass spectrometry. The course takes
the student through advanced topics like 2D FTICR mass spectrometry, an
expansive full view of modern mass spectrometric methods and their practical use
in research and industry.
This guide is designed to introduce young students
aged between 6 and 14 to the field of mass spectrometry in a highly interactive
and hands-on laboratory experience. It describes the basic principles of the
technique in a way that is fun and accessible for children. It can be adapted in
modules to accomodate various age groups, providing an educational approach to
an introduction to the field of mass spectrometry. This resource sparks young
minds toward exploration of scientific concepts, especially in chemistry and
biology, and encourages curiosity about the world of molecular analysis.
This note presents
an overview of mass spectrometry at an advanced level with specific emphasis on
its utility in chemistry and biochemistry. Fundamental concepts include
ionization, mass analyzers, and dissociation of ions, as well as more advanced
topics like ion mobility and fragmentation. The qualitative and quantitative
analysis using mass spectrometry and the practical applications in various
fields are also considered. This note is designed for advanced students and
professionals aiming to gain insights into the role of mass spectrometry as an
analytical tool, both in theory and practice.