Prof.
Peter B. O'Connor's note on mass spectrometry. It deals with the interpretation
of mass spectra; it would be particularly useful for any persons undertaking the
analysis of unknown samples. It starts by dealing with a range of techniques,
among them being electron impact ionization, MS/MS fragmentation, and ion
sources. In addition, the note goes into practical implementations of mass
spectrometry in real-world applications such as protein complex analysis,
hydrogen and deuterium exchange, and imaging mass spectrometry. The course takes
the student through advanced topics like 2D FTICR mass spectrometry, an
expansive full view of modern mass spectrometric methods and their practical use
in research and industry.
This is a comprehensive note on
X-ray spectroscopy techniques, aimed at detailing their applications in
different fields, with an emphasis on the special applications in nanoparticles
and molecular mechanisms. It begins with the introduction of XRF processes and
techniques followed by high-resolution X-ray spectroscopy using compound
semiconductor detectors and digital pulse processing systems. It also includes
analytic applications of X-ray techniques, including dispersive X-ray
spectroscopy as well as quantification in X-ray fluorescence spectrometry. In
addition, it approaches specialized uses such as time-resolved X-ray absorption
spectroscopy in the study of metalloproteins and the application of soft X-rays
in astrochemistry. The note concludes discussing nanoscale chemical analysis
that highlights energy dispersive X-ray spectroscopy (EDX) and transmission
electron microscopy (TEM) with relevance to the characterization of interfaces
and materials on the nanoscale.
This guide is designed to introduce young students
aged between 6 and 14 to the field of mass spectrometry in a highly interactive
and hands-on laboratory experience. It describes the basic principles of the
technique in a way that is fun and accessible for children. It can be adapted in
modules to accomodate various age groups, providing an educational approach to
an introduction to the field of mass spectrometry. This resource sparks young
minds toward exploration of scientific concepts, especially in chemistry and
biology, and encourages curiosity about the world of molecular analysis.